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Why Can Botox Cause a Droopy Eyelid, and What Happens Next?

A droopy eyelid after Botox usually comes from toxin spreading to the lid-lifting muscle. It is temporary, often settling within weeks and by about 3 months.

Short answer

A droopy eyelid after Botox usually happens when some of the toxin spreads from the forehead or frown area into the muscle that lifts the upper lid. It is temporary and typically improves as the toxin wears off, within weeks and at most about 3 months. Prescription eye drops can sometimes lift the lid slightly while waiting. A droop that comes with double vision, swallowing or breathing problems, or other stroke-like signs needs urgent assessment rather than waiting.

Key points

  • In frown-line trials, eyelid drooping (ptosis) affected about 3% of people treated.
  • The cause is usually toxin reaching a neighbouring muscle, not damage to the eye.
  • The weakness can last up to about 12 weeks before resolving.
  • Alpha-adrenergic eye drops may help lift the lid a little in the meantime.
  • Eyelid droop and eyebrow droop are different problems with different causes.

Why it happens

The upper eyelid is raised mainly by a muscle called the levator palpebrae superioris, which runs back from the lid inside the eye socket. Frown-line injections are placed in muscles just above it. DermNet, a dermatology reference, explains that the weakness results from spread of toxin from the injection site into adjacent muscle groups2.

The US prescribing information for Botox Cosmetic advises injectors to avoid the area near this lifting muscle, to place outer frown-muscle injections at least 1 cm above the bony ridge of the eye socket, not to inject closer than 1 cm above the central eyebrow, and to keep the dose accurate and as low as feasible1. These steps reduce the risk but cannot remove it entirely.

Eyelid droop vs eyebrow droop

People often describe both as a “droopy eye”, but they differ. Mayo Clinic lists droopy eyelids and crooked eyebrows separately among possible side effects3.

FeatureEyelid ptosisBrow ptosis
What dropsThe upper lid edge, covering more of the eyeThe eyebrow, sometimes making the lid look heavy
Usual mechanismToxin reaching the muscle that lifts the lidOver-relaxation of the forehead muscle that raises the brows
Trial frequency (Botox Cosmetic)3% in frown-line trials; 2% with forehead plus frown treatment12% with forehead plus frown treatment1
CourseTemporary; improves as the toxin wears off2Temporary; improves as the toxin wears off2
Figures from placebo-controlled trials in the US prescribing information. Rates in everyday practice are not well measured.

How common it is

In the glabellar (frown-line) trials, eyelid ptosis occurred in 13 of 405 treated participants (3%) and none given placebo1. When the forehead and frown lines were treated together, eyelid ptosis and brow ptosis each occurred in about 2%1. In crow’s feet trials, ptosis was not among the side effects reported in at least 1% of participants1.

These figures come from controlled trials with standard doses and experienced injectors. Rates outside trials, with varied products, doses and techniques, are not reliably known: Uncertain incidence.

What happens next

The droop usually appears days after treatment, as the toxin takes effect, and then gradually eases. DermNet notes that the weakness can persist for up to 12 weeks2. It does not cause lasting damage to the eye or the eyelid muscle in the usual case.

While waiting, a clinician may prescribe alpha-adrenergic eye drops, which can help a droopy eyelid or eyebrow2. The American Academy of Ophthalmology notes that one such drop, oxymetazoline, is used for some acquired droopy eyelids but does not work for drooping caused by injury or nerve problems4. Evidence for these drops specifically after botulinum toxin is Limited, and they are not suitable for everyone, so they should only be used on prescription.

The prescribing information advises avoiding driving or hazardous activities if drooping eyelids or blurred vision occur1.

When the cause may be something else

A droop after Botox is not always caused by Botox. Ageing stretches the eyelid-lifting muscle, and eye surgery, injury and, rarely, nerve or muscle diseases can also cause ptosis4. The prescribing information advises caution in people who already have ptosis before treatment1, so a pre-existing droop should be noted at assessment. A droop that does not fit the timing, or that persists well beyond 3 months, deserves an eye examination.

When to seek medical advice

Botulinum toxin effects can spread beyond the injection site hours to weeks afterwards, causing generalised weakness, double vision, drooping lids, or difficulty swallowing or breathing1. Contact a clinician straight away for muscle weakness, vision problems, or trouble speaking or swallowing3, and seek emergency care for breathing difficulty5.

If one side of the face droops, an arm is weak or speech becomes slurred, treat it as a possible stroke and call 999 in the UK (or local emergency services) rather than assuming it is a side effect6.

Common questions

How long does a droopy eyelid from Botox last?

It usually improves over a few weeks and can last up to about 12 weeks, as the toxin wears off2.

Is a droopy eyelid after Botox permanent?

No, a droop caused by toxin spread is temporary because the toxin’s effect itself is temporary. A droop that persists well beyond 3 months suggests a different cause and needs examination.

Was it caused by rubbing the area or lying down?

It is not possible to say in an individual case; aftercare advice not to rub or massage the area for 24 hours is meant to reduce spread3, but injection position and dose are the factors the prescribing information focuses on1.

Can I have Botox again after this happened?

Possibly, once the effect has fully worn off, but it is reasonable to review the dose, injection points and product with the clinician first, and to discuss whether the frown area should be treated at all.

Bottom line

Eyelid droop after Botox is an uncommon, recognised and temporary effect of toxin reaching the lid-lifting muscle. It usually settles within weeks to 3 months, and prescription drops may help a little meanwhile. New weakness elsewhere, double vision, or swallowing, breathing or speech problems are a different matter and need urgent care.

Sources

  1. US National Library of Medicine. BOTOX Cosmetic (onabotulinumtoxinA) prescribing information, revised October 2024. DailyMed; 2024. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=485d9b71-6881-42c5-a620-a4360c7192ab. Accessed 5 November 2026.
  2. Ip KH-K. Botulinum toxin. DermNet; 2020 (updated 2024). https://dermnetnz.org/topics/botulinum-toxin. Accessed 5 November 2026.
  3. Mayo Clinic. Botox injections. Mayo Clinic. https://www.mayoclinic.org/tests-procedures/botox/about/pac-20384658. Accessed 5 November 2026.
  4. American Academy of Ophthalmology. What is ptosis? AAO; 2026. https://www.aao.org/eye-health/diseases/what-is-ptosis. Accessed 5 November 2026.
  5. MedlinePlus. OnabotulinumtoxinA injection. US National Library of Medicine. https://medlineplus.gov/druginfo/meds/a608013.html. Accessed 5 November 2026.
  6. NHS. Stroke: symptoms. NHS website. https://www.nhs.uk/conditions/stroke/symptoms/. Accessed 5 November 2026.

Article history

  • — First published.